Author

Annekathrin Silvia Nedwed

Johannes Gutenberg University MainzORCID 0000-0002-2475-4945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Fédérico MariniiD· 2 shared Michael DelacheriD· 2 shared Sara Salome HelbichiD· 2 shared Alicia PoplawskiiD· 1 shared Andreas Henkel· 1 shared Arsenij UstjanzewiD· 1 shared Benedikt BrorsiD· 1 shared Christoph EckertiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioinformatics

Fédérico MariniORCID

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2 papers

Recent·Most cited

GeDi: Simplifying Gene Set Distances for Enhanced Omics Interpretation in R/Bioconductor

Annekathrin Silvia Nedwed, Arsenij Ustjanzew, Najla Abassi, Leon Dammer, Alicia Poplawski, Sara Salome Helbich, Michael Delacher, Konstantin Strauch, Fédérico Marini

GeDi streamlines functional enrichment results by clustering gene sets and integrating PPI data, improving interpretation and hypothesis generation.

BMC Bioinformatics · Dec 7, 2025Peer-reviewedBioinformatics

Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells

Kathrin Luise Braband, Tamara Kaufmann, Niklas Beumer, Malte Simon, Sara Salome Helbich, Delia Mihaela Mihoc, Morten Michael Voss, Annekathrin Silvia Nedwed, Katharina Bauer, Jan‐Philipp Mallm, Tanja Ziesmann, Ute Distler, Stefan Tenzer, Christoph Eckert, Michael Volkmar, , Michael Delacher

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.

bioRxiv · May 14, 2025 · PreprintImmunology