Malte Simon

The paper integrates neuroimaging, omics, and single nucleus-RNA-Seq data to show glymphatic dysfunction in schizophrenia is linked to inflammation, aging, and cognitive decline.

The paper identifies a disease-associated microglial state in AD using transcriptomics and shows a compound can reverse it.

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.

The paper introduces CFS, a method to compare cell groups across datasets without integration, identifying conserved astrocyte subpopulations in mouse motor cortex and spinal cord.

This paper develops a computational framework to quantify telomere content and composition from scATAC-seq data, revealing patient-specific telomere maintenance patterns in cancer and immune cells.