Michael Delacher

Treg-derived IκBζ promotes their conversion into Th2-like effectors and drives type 2 inflammation via BATF

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

Menin-Inhibition Sensitizes Acute Myeloid Leukemia to CLEC12A-Directed CAR Cell Therapy

This paper shows menin inhibitors increase CLEC12A expression in AML, making it more responsive to CLEC12A-targeted CAR T cells, improving treatment outcomes.

GeDi: Simplifying Gene Set Distances for Enhanced Omics Interpretation in R/Bioconductor

GeDi streamlines functional enrichment results by clustering gene sets and integrating PPI data, improving interpretation and hypothesis generation.

KDM6B inhibition modulates monocyte activation and alleviates IMQ-psoriasis skin inflammation

This paper shows that inhibiting KDM6B reduces monocyte activation and skin inflammation in a psoriasis model by restoring H3K27me3 and suppressing inflammatory gene expression.

Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.

Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice

This study investigates the functional differences between thymic and peripheral Treg cells in visceral adipose tissue, showing that tTreg instability contributes to inflammation and obesity while pTreg cells protect against metabolic disorders.