Exploration of cell development pathways through high dimensional single cell analysis in trajectory space
Denis Đermadi, Michael Bscheider, Kristina Bjegovic, Nicole H. Lazarus, Agata Szade, Husein Hadeiba, Eugene C. Butcher
The paper introduces tSpace, a computational method for analyzing developmental pathways in single-cell data, and shows it reconstructs known developmental sequences and reveals new insights into B cell development and intestinal epithelial differentiation.
iScience · Jan 16, 2020Peer-reviewedBioinformatics