This study investigates how heme oxygenase-1 (HO1) affects interferon-stimulated gene (ISG) expression in response to various stressors, finding that TNF is a key inducer and HO1 influences nuclear retention of inflammatory transcription factors.

Journal of Inflammation · Oct 9, 2025Peer-reviewedImmunology

Dose- and time-dependent effects of cobalt protoporphyrin IX on granulocyte mobilization and metabolic markers in mice

Aleksandra Bednarz, Paweł Kożuch, Kacper Kowalski, Izabella Skulimowska, Neli Kachamakova‐Trojanowska, Jadwiga Filipek-Gorzała, Patrycja Kwiecińska, Raquel García-García, Kinga Gawlińska, Kinga Mależyna, Andrzej Kubiak, Natalia Bryniarska, Alicja Józkowicz, Krzysztof Szade, Agata Szade

This study evaluates the dose- and time-dependent effects of CoPP on granulocyte mobilization and metabolic markers in mice, finding a dose-dependent mobilizing effect with mild side effects.

Pharmacological Reports · Jul 9, 2025Peer-reviewedPharmacology & Toxicology

Exploration of cell development pathways through high dimensional single cell analysis in trajectory space

Denis Đermadi, Michael Bscheider, Kristina Bjegovic, Nicole H. Lazarus, Agata Szade, Husein Hadeiba, Eugene C. Butcher

The paper introduces tSpace, a computational method for analyzing developmental pathways in single-cell data, and shows it reconstructs known developmental sequences and reveals new insights into B cell development and intestinal epithelial differentiation.

iScience · Jan 16, 2020Peer-reviewedBioinformatics