Eugene C. Butcher

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study identifies transcriptional networks that coordinate metabolic and secretory pathways in high endothelial cells (HECs) to support immune function and morphology.

This study identifies transcription factors that induce vascular blood stem cell niches in vivo, enabling synthetic niche generation and potential therapeutic applications.

This paper uses single-cell transcriptomics to map the transcriptional organization of lymphatic endothelial cells in mouse and human lymph nodes, identifying distinct subsets and their functional roles.

The paper introduces tSpace, a computational method for analyzing developmental pathways in single-cell data, and shows it reconstructs known developmental sequences and reveals new insights into B cell development and intestinal epithelial differentiation.

This study shows aged blood reduces hippocampal neurogenesis and activates microglia via VCAM1 at the BBB, and blocking VCAM1 reverses these effects.