BiophysicsThe Journal of Physical Chemistry LettersPeer-reviewed
Kinetic model for the desensitization of G protein-coupled receptor
Won Kyu Kim, Yoonji Lee, Seogjoo Jang, Changbong Hyeon
The paper develops a kinetic model to understand GPCR desensitization by integrating biochemical steps from ligand binding to receptor internalization, identifying three downregulation regimes based on phosphorylation, dephosphorylation, and beta-arrestin levels.