Shihao He

Xenium In Situ Profiling Uncovers HSPG-Dependent SULF1/VEGFR2 Signaling Mediating Vascular Remodeling in Moyamoya Disease

The paper uses spatial transcriptomics and functional experiments to show SULF1 enhances VEGFR2 signaling and vascular remodeling in Moyamoya Disease.

Spatial Multi-Omics Reveals Extracellular Matrix Remodeling and VSMC Phenotypic Switching in Moyamoya Disease

This study uses spatial multi-omics to show ECM remodeling and VSMC phenotypic switching in Moyamoya Disease, linking FN1-ITGA5-FAK pathway activation to metabolic changes in the intimal niche.

Organoid Modeling and Single-Cell Profiling Uncover the Migration Mechanism of Smooth Muscle Cells in Moyamoya Disease

This study uses organoid models and single-cell profiling to identify TUBA4A and TUBB4B overexpression as drivers of vascular smooth muscle cell dysfunction in Moyamoya Disease.