GeneticsbioRxivPreprint
MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromes
Karim Harhouri, Pierre Cau, Frank A Casey…·Nicolas Lévy
This study shows that MG132 reduces Progerin levels and improves cellular phenotypes in HGPS-like patient fibroblasts through autophagy and splicing regulation.
DOI 10.1101/2021.04.14.439612