MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromes
Karim Harhouri, Pierre Cau, Frank A Casey, K.M. Guedenon, Yassamine Doubaj, Lionel Van Maldergem, Gerardo Mejia-Baltodano, Catherine Bartoli, Annachiara De Sandre‐Giovannoli, Nicolas Lévy
This study shows that MG132 reduces Progerin levels and improves cellular phenotypes in HGPS-like patient fibroblasts through autophagy and splicing regulation.
bioRxiv · Apr 14, 2021 · PreprintGenetics