Filip Leonarski

Rugnux processes diffraction images from synchrotrons and XFELs into merged data and initial structures quickly and efficiently on a single GPU.

This paper introduces TR-FRX, a method to study protein dynamics during enzymatic catalysis using time-resolved crystallography, and applies it to lysozyme and malate dehydrogenase.

The paper establishes principles of Mg2+ ion binding to RNA using a high-resolution bacterial ribosome structure, revealing new motifs and dehydration processes involved in RNA folding and ribosome biogenesis.