Rafael Siqueira Chagas

The paper presents a unified enzyme kinetic model that integrates six inhibition mechanisms into a single framework, showing they are facets of the same model.

This study examines how buffer ionic concentration and mutations affect the homodimerization of Sfβgly, revealing the hydrophobic effect's role and the importance of specific residues in dimer stability.

GOLF predicts the pathogenicity of myocilin OLF domain variants using generative AI and interpretable models, achieving accurate classification of known pathogenic and benign variants.

This paper shows Tris inhibits GH1 β-glucosidase via linear mixed inhibition, reducing enzyme-substrate affinity and affecting kinetic parameters.