Yixuan Ye

This paper introduces GENJI, a method to estimate genetic correlation using both individual-level and summary-level GWAS data, improving accuracy and efficiency over existing methods.

The paper uses whole-exome sequencing to identify rare genetic variants in CYP2R1 associated with ischemic stroke risk and related brain imaging traits.

This study introduces SUPERGNOVA, a framework for estimating local genetic correlations, and identifies 150 trait pairs with significant local genetic correlations, including autism spectrum disorder and cognitive performance.

This study benchmarks methods for estimating genetic correlation between complex traits using GWAS summary statistics, highlighting challenges like LD dependency and sample overlap.

The paper investigates the association between age-related mosaic chromosomal alterations and infection risk in 767,891 individuals without blood cancer, finding increased infection susceptibility linked to mCAs.