Guido J. Falcone

This study shows that adverse polygenic profiles for dementia are linked to higher risks of dementia, disability, or death in middle-aged and older adults.

The paper identifies proteomic and transcriptomic differences between ischemic stroke patients with atrial fibrillation and carotid atherosclerosis using integrated multi-omics analyses.

ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.

This study finds that higher polygenic susceptibility to type 2 diabetes is associated with worse glycemic control and higher risk of cardiovascular events in stroke survivors.

Genal provides a Python toolkit for genetic risk scoring and Mendelian Randomization, streamlining population genetic analyses with user-friendly functions.

This study identifies shared genetic loci and genes between PTSD and cardiovascular conditions using GWAS across multiple data sources and finds overlapping biological pathways and drug targets.

The paper performs deep resequencing of the 1q22 locus in non-lobar ICH cases and controls to identify causal variants and mechanisms.

The paper describes how the Yale Generations Project adapted its recruitment, consent, and DNA sample acquisition processes to remote methods during the COVID-19 pandemic, resulting in continued enrollment and sample collection.

This paper develops a genomic risk score for intracerebral hemorrhage using genome-wide association data and validates its predictive power in multiple cohorts.

The paper uses whole-exome sequencing to identify rare genetic variants in CYP2R1 associated with ischemic stroke risk and related brain imaging traits.

The paper identifies subtype-specific genetic loci associated with stroke subtypes and finds heterogeneity in their effects across different stroke types.

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.