Sixing Chen

Combined single-cell RNA-seq profiling and enhancer editing reveals critical spatiotemporal controls over thalamic nuclei formation in the murine embryo

The paper uses single-cell RNA-seq and enhancer editing to study thalamic nuclei formation in mice, revealing lineage-specific gene expression programs and their role in neurodevelopmental disorders.

ACAT: A Fast and Powerful P-value Combination Method for Rare-variant Analysis in Sequencing Studies

ACAT improves power for rare-variant analysis by combining p-values using two tests, ACAT-V and ACAT-O, showing robustness and higher power than existing methods.