Marc Vincent Fuccillo

Brain-Resident CD8+ T Cells Regulate Neuronal Activity and Behavior via Interferon-Gamma

This study identifies brain-resident CD8+ T cells that regulate neuronal activity and behavior through interferon-gamma secretion, showing their role in maintaining brain homeostasis.

Striatal interneuron microcircuits gate reinforcement to stabilize adaptive choice

This study identifies a striatal interneuron circuit that gates reinforcement by linking outcome processing to adaptive action selection through disinhibitory microcircuitry.

Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior

The paper identifies indirect pathway neurons in the tail of the striatum as critical for inhibitory control over sensory-driven behavior, showing their role in suppressing inappropriate actions and linking their dysfunction to neurodevelopmental disorders.

Comprehensive 3D mapping reveals distinct spatial gradients of SST, PV, and TH interneurons across the mouse caudoputamen

The paper creates a 3D atlas of SST, PV, and TH interneurons in the mouse caudoputamen, revealing distinct spatial distributions across striatal territories.

Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling

This study shows that H2BE is required for activity-dependent gene expression and homeostatic scaling in neurons.

An Open-Source Joystick Platform for Investigating Forelimb Motor Control, Auditory-Motor Integration, and Value-Based Decision-Making in Head-Fixed Mice

This paper introduces an open-source joystick platform for training head-fixed mice in auditory-motor and value-based decision-making tasks, providing rich behavioral and motor data.

Temporally and Functionally Distinct Contributions to Value Based Choice Along the Anterior-Posterior Dorsomedial Striatal Axis

This study investigates how different regions of the dorsomedial striatum contribute to value-based decision-making in mice through distinct temporal coding patterns and neural activity.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory

This study identifies H2BE as a widely expressed H2B variant that enhances chromatin accessibility in neurons, promoting synaptic gene expression and long-term memory.

A chromosome region linked to neurodevelopmental disorders acts in distinct neuronal circuits in males and females to control locomotor behavior

This study identifies sex- and cell type-specific transcriptomic and behavioral effects of 16p11.2 hemideletion in mice, revealing distinct impacts on striatal circuits and locomotor behavior.

Infralimbic activity during REM sleep facilitates fear extinction memory

This study shows that REM sleep after fear conditioning enhances infralimbic cortex excitability, which is crucial for fear extinction memory consolidation.

Combined single-cell RNA-seq profiling and enhancer editing reveals critical spatiotemporal controls over thalamic nuclei formation in the murine embryo

The paper uses single-cell RNA-seq and enhancer editing to study thalamic nuclei formation in mice, revealing lineage-specific gene expression programs and their role in neurodevelopmental disorders.

Distributed processing for action control by prelimbic circuits targeting anterior-posterior dorsal striatal subregions.

The paper identifies distinct prefrontal circuits targeting anterior and posterior dorsal striatum subregions and characterizes their roles in action control during a choice task.

Striatal low-threshold spiking interneurons locally gate dopamine during learning

The paper shows that LTSIs in the dorsomedial striatum gate dopamine release via GABAB signaling during learning.

Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction

This study investigates how Neurexin1 mutations in specific brain circuits affect value-based decision-making and identifies neural mechanisms underlying cognitive dysfunction in neuropsychiatric disorders.

Neurexin1α differentially regulates synaptic efficacy within striatal circuits

This study shows that Neurexin1 regulates synaptic strength specifically in striatal indirect pathway spiny neurons, but not in thalamic inputs.

A cortical pathway modulates sensory input into the olfactory striatum

This study investigates the functional role of the cortico-striatal pathway from the piriform cortex to the olfactory tubercle in mice, showing it modulates odor coding through monosynaptic connections.