Author

Madison Chapel

University of British ColumbiaORCID 0000-0002-2661-2916Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Approach:simulation· 1

Frequent Co-Authors

Carl G. de BoeriD· 2 shared Jessica Kiri DennisiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBioinformatics

Carl G. de BoerORCID

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2 papers

Recent·Most cited

BioinformaticsGenome Biology and EvolutionPeer-reviewedAug 1, 2026

Evolutionary simulations reveal role for genomic recombination in the evolution of gene regulatory network complexity and robustness

Madison Chapel, Carl G. de Boer

This study uses evolutionary simulations to show that recombination affects the rate of regulatory complexity emergence in gene networks, but not its final level.

DOI 10.1093/gbe/evag196

simulation

𝕏 PostBluesky

GenomicsCell GenomicsPeer-reviewedJan 26, 2026

Polygenic backgrounds influence phenotypic consequences of variants in cells, individuals, and populations

Madison Chapel, Jessica Kiri Dennis, Carl G. de Boer

The paper shows that polygenic backgrounds affect the phenotypic impact of genetic variants across different levels, suggesting that selection coefficients vary with genetic context.

3 citations

human

𝕏 PostBluesky