Jessica Kiri Dennis

This study evaluates polygenic risk scores for Parkinson's disease in admixed Latin American populations, finding that European-derived PRS outperform ancestry-matched but underpowered datasets.

The paper shows that polygenic backgrounds affect the phenotypic impact of genetic variants across different levels, suggesting that selection coefficients vary with genetic context.

The paper introduces methods to clean and analyze clinical lab data linked to EHRs, finding polygenic scores associated with lipid levels and coronary artery disease biomarkers.

This study identifies genetic risk factors for major depressive disorder and loneliness as predictors of coronary artery disease risk, particularly in women.

The paper develops a polygenic risk score integrating AD biomarkers and shows it better predicts cognitive decline than a clinical AD-based PRS.

This study identifies 12 genetic loci associated with loneliness and finds genetic correlations with 34 health outcomes, including cardiovascular and psychiatric disorders.

This study evaluates polygenic risk scores for schizophrenia in electronic health records, finding strong associations with schizophrenia and pleiotropic effects on other psychiatric and medical conditions.