Inference and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis.
Simon J. Haworth, Pik Fang Kho, Pernilla Lif Holgerson, Liang‐Dar Hwang, Nicholas John Timpson, Miguel E. Rentería, Ingegerd Johansson, Gabriel Cuéllar-Partida
The paper develops an automated pipeline using the latent causal variable approach to infer phenome-wide causal relationships, applying it to dental caries and periodontitis to show they are downstream consequences of other traits.
European Journal of Human Genetics · Oct 3, 2020Peer-reviewedGenetics