Pik Fang Kho

The paper investigates why the 9p21.3 CAD risk locus fails to replicate in African ancestry cohorts, finding ancestry-specific LD and haplotype diversity explain the lack of association.

This study uses Mendelian randomization to show that higher glycemic traits are inversely associated with thoracic aortic diameters and reduced risk of aneurysm and dissection.

This study identifies plasma proteins associated with insulin sensitivity across diverse populations and shows their response to interventions, with some proteins suggesting causal relationships and therapeutic targets.

This study identifies plasma proteomic signatures that modestly improve prediction of incident type 2 diabetes compared to clinical and genetic factors.

The paper identifies CXCL12 as a genetic driver of coronary artery anatomy variation through GWAS and mouse models, showing its role in fetal coronary development.

This paper develops a plasma proteomic signature for predicting atherosclerotic cardiovascular disease risk using UK Biobank data and finds it modestly improves prediction over clinical and genetic factors.

This study identifies 49 genetic loci associated with sleep apnoea risk using multi-trait GWAS, with 29 replicated in a large cohort, and finds genetic correlations with several complex traits.

This study uses GWAS summary data to identify 110 traits with significant causal associations with obesity, revealing its broad impact on cardiovascular, anthropometric, and psychiatric conditions.

This study identifies genetic correlations and causal associations between circadian preference and white matter microstructure using GWAS and DTI data.

The paper develops an automated pipeline using the latent causal variable approach to infer phenome-wide causal relationships, applying it to dental caries and periodontitis to show they are downstream consequences of other traits.

A web platform bundling LD-score regression, DEPICT, MetaXcan, SMR, GSMR and fastBAT over uploaded or 1,500-plus public GWAS summary statistics, with precomputed gene, pathway and tissue results.