BioinformaticsPLoS Computational BiologyPeer-reviewed
Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods
Wei‐Yu Lin, Melissa Kartawinata, Bethany R. Jebson…·Chris Wallace
This paper compares methods for imputing cell-type specific expression from mixed RNA-seq data, finding that machine learning methods like LASSO and ridge outperform domain-specific methods in recovering differential gene expression.
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