Extracellular Matrix Mechanobiology in Pancreatic Ductal Adenocarcinoma: Correlating In Vivo Patient Magnetic Resonance Elastography with Ex Vivo Tissue Mechanics and Histopathology
Oihane Mitxelena‐Iribarren, Daniela S. Garske, Dag Wulsten, Iñigo Mendizabal-Arrieta, Kristin Susan Spirgath, Salma Almutawakel, Rosa Bianca Schmuck, Ingolf Sack, Amaia Cipitria
This study correlates in vivo MRE-derived mechanical properties with ex vivo tissue mechanics and histopathology in PDAC, showing that softer surrounding environments are linked to stiffer tumors and poorer prognosis.
bioRxiv · Jun 10, 2026 · PreprintBioengineering