Ingolf Sack

This study correlates in vivo MRE-derived mechanical properties with ex vivo tissue mechanics and histopathology in PDAC, showing that softer surrounding environments are linked to stiffer tumors and poorer prognosis.

This study shows that elevated dietary cholesterol in rats leads to liver lipid crystals, which increase tissue stiffness and fibrosis progression in a model of MASLD.

This paper introduces OMTHE to map microscale stiffness changes during collagen polymerization and crosslinking with high spatiotemporal resolution.

This study shows that liver viscosity decreases before fibrosis in a mouse model of MASH, indicating it as a potential early biomarker.

This study uses in vivo MR elastography to show early whole-liver viscoelastic changes in a murine HCC model, suggesting biomechanical adaptation beyond the tumor microenvironment.