Chronotherapy as a Potential Strategy to Reduce Ifosfamide-Induced Encephalopathy: A Preclinical Study in a Murine Model
Malek Chennoufi, Dorrà Dridi, Khaled Lasram, Nouha Ben Abdeljalil, Asma Omezzine, Benoît Mauvieux, Yvan Touitou, Ahmed Sleheddine Masmoudi, Naceur A. Boughattas
This study shows that sublethal ifosfamide toxicity varies by time of day in mice, with reduced organ damage at 13 HALO compared to other times.
bioRxiv · Aug 28, 2025 · PreprintPharmacology & Toxicology