Author

Yi Han

Baylor College of MedicineORCID 0000-0002-2835-9280Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yi Han3 papers · Cleveland Clinic

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:database / resource· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Donna Marie MuznyiD· 2 shared Fritz Joachim SedlazeckiD· 2 shared Richard A. GibbsiD· 2 shared Shalini N. JhangianiiD· 2 shared Adam C. EnglishiD· 1 shared Carvalho Claudia· 1 shared Casey Riegler· 1 shared Christine C. Lambert· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Donna Marie MuznyORCID

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2 papers

Recent·Most cited

Enriching for Answers in Rare Diseases

Yilei Fu, Adam C. English, Luis F. Paulin, Shalini N. Jhangiani, George Weissenberger, Vanessa Vee, Yi Han, Heer Hemant Mehta, Donna Marie Muzny, Richard A. Gibbs, Jennifer E. Posey, Daniel G. Calame, Fritz Joachim Sedlazeck

TBAS enables cost-effective long-read sequencing of rare-disease trios with high variant detection accuracy and a 77% potential solve rate.

medRxiv · Oct 21, 2025 · PreprintGenetic & Genomic Medicine

Closing the gap: Solving complex medically relevant genes at scale

Medhat Mahmoud, John Harting, Holly Corbitt, Xiao Chen, Shalini N. Jhangiani, HarshaVardhan Doddapaneni, Qingchang Meng, Christine C. Lambert, Siyuan Zhang, Primo A. Baybayan, Geoff Henno, Tina Han, Yi Han, Casey Riegler, Ginger Metcalf, , Fritz Joachim Sedlazeck

The paper introduces a targeted sequencing framework, TADGP, that accurately calls variants in complex medically relevant genes at lower cost than HiFi-WGS, enabling scalable analysis of dark genomic regions.

medRxiv · Mar 14, 2024 · PreprintGenetic & Genomic Medicine