Author

Saskia M. Wilting

Erasmus MCORCID 0000-0002-2838-841XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Approach:statistical model· 1

Frequent Co-Authors

Joachim BoersiD· 2 shared John W.M. MartensiD· 2 shared Joost H. GribnauiD· 2 shared Ruben BoersiD· 2 shared Stavros MakrodimitrisiD· 2 shared Vanja de Weerd· 2 shared Bram PronkiD· 1 shared Cornelis Kees VerhoefiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersBioinformatics

Joachim BoersORCID

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Author profile →

3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 26, 2026

Cell-free DNA Fragmentation Profiling at Transcription Start Sites Improves upon Cancer-Type-Specific Region Selection for Cancer Detection

Bram Pronk, Stavros Makrodimitris, Saskia M. Wilting, Marcel J. T. Reinders

The paper develops a data-driven framework to detect cancer using cfDNA fragmentation patterns at TSSs, outperforming existing methods in distinguishing cancer from healthy samples.

DOI 10.64898/2026.06.22.733692

humanwhole-genome sequencing

Bioinformaticsnpj Precision OncologyPeer-reviewedDec 15, 2025

Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from Methylated DNA Sequencing data (MeD-seq)

Daan M. Hazelaar, Ruben Boers, Joachim Boers…·Saskia M. Wilting

The paper introduces MeD-seq, a method to profile circulating tumor DNA by analyzing DNA methylation and copy number changes, showing its effectiveness in detecting cancer-specific signals in plasma samples.

3 citations

humanDNA methylation

GenomicsClinical EpigeneticsPeer-reviewedOct 20, 2021

High throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by Methylated DNA sequencing (MeD-seq) of LpnPI digested fragments

Teoman Deger, Ruben Boers, Vanja de Weerd…·Saskia M. Wilting

This paper validates MeD-seq for cfDNA methylation profiling in cancer patients, showing distinct pre-surgical methylation patterns compared to healthy donors.

29 citations

humanDNA methylation