CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor.
Rajendra Kumar, Janet Mendonca, Abhishek Shetty, Yuhan Yang, Olutosin Owoyemi, Lillian Wilson, Kavya Boyapati, Deven Topiwala, Naiju Thomas, Huong P. T. Nguyen, Jun Luo, Channing Judith Paller, Samuel Ray Denmeade, Michael Anthony Carducci, Sushant K. Kachhap
This study shows CRM1 regulates androgen receptor stability and DNA repair in prostate cancer, suggesting combination therapy with CRM1 and DNA repair inhibitors could be effective.
The FASEB Journal · Jan 28, 2025Peer-reviewedCancer Biology