Jesse A. Sharp

Implementation and acceleration of optimal control for systems biology

This paper reviews optimal control theory in systems biology, implements the forward-backward sweep method, and accelerates its convergence using existing techniques.

Persistence as an optimal hedging strategy

The paper develops a theoretical framework for understanding bacterial persistence as a hedging strategy by integrating optimal control theory from finance and mathematical biology.

Designing combination therapies using multiple optimal controls

This paper applies optimal control theory to design combination therapies for acute myeloid leukaemia by analyzing control dynamics and pay-off functions.

Optimal control of acute myeloid leukaemia

This paper develops optimal chemotherapy strategies for AML by incorporating immune response into a stem cell model and applying optimal control theory.