Tarunendu Mapder

PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell

PhysiPKPD integrates pharmacokinetics and pharmacodynamics into PhysiCell models to enhance in silico simulations of molecular therapies.

Persistence as an optimal hedging strategy

The paper develops a theoretical framework for understanding bacterial persistence as a hedging strategy by integrating optimal control theory from finance and mathematical biology.

Designing combination therapies using multiple optimal controls

This paper applies optimal control theory to design combination therapies for acute myeloid leukaemia by analyzing control dynamics and pay-off functions.

Administration of defective virus inhibits dengue transmission into mosquitoes

The paper models dengue transmission from humans to mosquitoes and shows that administering defective virus reduces viral load and inhibits transmission.

Iterative community-driven development of a SARS-CoV-2 tissue simulator

Open-source agent-based PhysiCell model of SARS-CoV-2 infection in lung epithelium; version 5 clears virus in about 6 days in simulation, and delayed T cell arrival increases epithelial loss.

A population of bang-bang switches of defective interfering particles makes within-host dynamics of dengue virus controllable

The paper evaluates the effect of defective interfering particles on dengue virus within-host dynamics using population of models to estimate their therapeutic potential.

Optimal control of acute myeloid leukaemia

This paper develops optimal chemotherapy strategies for AML by incorporating immune response into a stem cell model and applying optimal control theory.