Agustín E. Carpaneto Freixas

The paper investigates the reduced efficacy of choline as an agonist at mammalian 910 nicotinic acetylcholine receptors, linking this change to evolutionary adaptations in the 10 subunit.

The paper identifies α9-containing nicotinic acetylcholine receptors (α9* nAChRs) at the zebrafish lateral line efferent synapse, showing they mediate ACh-induced inhibition of hair cell activity through SK potassium channels.

The paper compares evolutionary trajectories of neuronal and hair cell nicotinic acetylcholine receptors across tetrapods, finding distinct patterns in sequence conservation, co-expression, and functional properties.