Ana Belén Elgoyhen

This study examines how altered medial olivocochlear (MOC) activity affects synaptic structure and function in the auditory brainstem using mouse models.

The paper shows that GABA and ACh are co-released from MOC terminals, modulating cholinergic inhibition at IHC synapses during development.

This study shows that enhancing medial olivocochlear feedback protects against early noise-induced hearing damage in mice, with long-term auditory benefits.

This paper shows that endocannabinoids stimulate the insulin pathway to modulate cholesterol mobilization in C. elegans.

The paper investigates Ca2+ influx mechanisms in cochlear outer hair cells, finding that synaptic VGCCs and MOC synapses contribute differently to Ca2+ homeostasis, with sorcin playing a regulatory role.

The paper investigates the reduced efficacy of choline as an agonist at mammalian 910 nicotinic acetylcholine receptors, linking this change to evolutionary adaptations in the 10 subunit.

The paper shows that purinergic signaling via ATP release from inner supporting cells drives spontaneous activity in the auditory system from birth to hearing onset, promoting coordinated neural firing in frequency-specific circuits.

The paper identifies α9-containing nicotinic acetylcholine receptors (α9* nAChRs) at the zebrafish lateral line efferent synapse, showing they mediate ACh-induced inhibition of hair cell activity through SK potassium channels.

The paper compares evolutionary trajectories of neuronal and hair cell nicotinic acetylcholine receptors across tetrapods, finding distinct patterns in sequence conservation, co-expression, and functional properties.

This study shows that enhancing efferent olivocochlear activity disrupts topographic organization and synaptic function in the medial nucleus of the trapezoid body.

The paper examines developmental changes in the MOC-IHC synapse, showing increased transmitter release and shifts in short-term plasticity properties during postnatal development.