This study investigates the effects of aging and vitamin D on LINE-1 DNA methylation in haematopoietic progenitors, finding no effect of vitamin D but age-related differences.

bioRxiv · May 2, 2020 · PreprintGenetics

Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent MS risk

Lawrence T. C. Ong, Stephen D. Schibeci, Nicole Fewings, David Richmond Booth, Grant Peter Parnell

The paper investigates how vitamin D exposure affects DNA methylation at VDR binding sites in myeloid cells, linking age-dependent changes to latitude-related multiple sclerosis risk.

bioRxiv · Apr 27, 2020 · PreprintGenetics

Genetic evidence that the latency III stage of Epstein-Barr Virus infection is a therapeutic target for Multiple Sclerosis

Ali Afrasiabi, Grant Peter Parnell, Nicole Fewings, Stephen D. Schibeci, Monica A. Basuki, Ramya Chandramohan, David Alexander Brown, Sanjay Swaminathan, Fiona C. McKay, Graeme J. Stewart, David Richmond Booth

The paper identifies EBV latency III stage as a therapeutic target for MS by linking MS risk SNPs to EBV transcription factors and miRNAs.

bioRxiv · Aug 13, 2018 · PreprintGenomics

Mortality prediction in sepsis via gene expression analysis: a community approach

Timothy E. Sweeney, Thanneer Malai Perumal, Ricardo Henao, Marshall Nichols, Judith A. Howrylak, Augustine M.K. Choi, Jesús F. Bermejo-Martín, Raquel Almansa, Eduardo Tamayo, Emma E. Davenport, Katie L. Burnham, Charles Hinds, Julian Charles Knight, Christopher W. Woods, Stephen Francis Kingsmore, , Raymond J. Langley

The paper develops gene-expression-based prognostic models for 30-day mortality in sepsis using community-onset and hospital-acquired sepsis cohorts, showing improved prediction when combined with clinical scores.

Nature Communications · Feb 9, 2018Peer-reviewedBioinformatics