Katie L. Burnham

Integrating bacterial genomics and host transcriptomics links Burkholderia pseudomallei variation to melioidosis mortality and neutrophil responses

Maternal immune gene expression trajectories and dynamic genetic regulation throughout pregnancy

This study tracks maternal immune gene expression and genetic regulation throughout pregnancy, revealing dynamic changes and genetic interactions linked to pregnancy complications.

Single-cell multi-ancestry regulatory map of systemic lupus erythematosus

The paper constructs a multi-ancestry single-cell eQTL map for SLE, identifying colocalized eQTLs with GWAS loci and highlighting cell-type-specific regulatory mechanisms.

Single-cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus

This study uses single-cell profiling to track B cell depletion and repopulation in SLE patients after rituximab treatment, revealing changes in B cell subsets and immune cell dynamics.

Trans-eQTLs reveal the architecture of human gene regulatory networks

The paper maps cis- and trans-eQTLs in blood samples to infer gene regulatory networks and prioritize trait-relevant pathways.

Integrating Natural and Engineered Genetic Variation to Decode Regulatory Influence on Blood Traits

The paper combines natural and engineered genetic variation to identify 22 non-coding variants affecting haematological traits and shows how a CUX1 variant impacts megakaryopoiesis.

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

The paper identifies USP18 as a negative regulator of interferon response at a lupus risk locus through trans-eQTL analysis in lymphoblastoid cell lines.

Genetic determinants of blood gene expression and splicing and their contribution to molecular phenotypes and health outcomes

This study identifies genetic determinants of blood gene expression and splicing, linking them to molecular phenotypes and health outcomes through QTL analysis and colocalization.

Misexpression of inactive genes in whole blood is associated with nearby rare structural variants

The paper identifies misexpression of inactive genes in whole blood and links it to nearby rare structural variants using RNA and genome sequencing data.

eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis

The paper identifies eQTLs and regulatory networks linking genetic variation to transcriptomic responses in sepsis, highlighting key regulators like HIF1A and CEBPB.

Identification of deleterious neutrophil states and altered granulopoiesis in sepsis

The paper identifies deleterious neutrophil states and altered granulopoiesis in sepsis using single-cell multi-omics data from sepsis patients and controls.

Mortality prediction in sepsis via gene expression analysis: a community approach

The paper develops gene-expression-based prognostic models for 30-day mortality in sepsis using community-onset and hospital-acquired sepsis cohorts, showing improved prediction when combined with clinical scores.