Christopher W. Woods

This study identifies how genetic and environmental factors shape the human immune cell epigenome through differential methylation and chromatin accessibility changes.

The paper quantifies proteins and post-translational modifications in dried blood from sepsis patients in Tanzania, revealing proteome signatures of inflammation and correlations with clinical markers.

The paper analyzes the epigenomic changes in innate immune cells after influenza virus infection and finds coordinated rewiring of the epigenetic landscape.

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

This paper provides a comprehensive guide for quality control metrics and mitigation strategies for 11 epigenetics and transcriptomics assays to improve exposure signature discovery.

The paper identifies a nonsynonymous ERAP1 variant associated with increased susceptibility to influenza virus using scHi-HOST, a single-cell method for genetic susceptibility testing.

The paper connects genetic architecture of human diseases with molecular phenotypes to uncover mechanisms of COVID-19 susceptibility.

Chromatin accessibility in immune cells from COVID-19 subjects is remodeled prior to seroconversion to reflect disease severity.

The paper develops gene-expression-based prognostic models for 30-day mortality in sepsis using community-onset and hospital-acquired sepsis cohorts, showing improved prediction when combined with clinical scores.