James Walters

Rare genetic variants influence participation in cognitive components of the UK Biobank

The paper shows rare genetic variants influence participation in cognitive tests of the UK Biobank, affecting the representativeness of the cohort and power of association studies.

Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

Identifying and Characterising Common Genetic Differences in Schizophrenia and Bipolar Disorder

This study identifies genetic variants differentially associated with schizophrenia and bipolar disorder using CC-GWAS, finding 19 loci with divergent effects and biological themes related to neuronal function.

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder

This study identifies genetic differences between fear-based anxiety disorders and generalised anxiety disorder using GWAS, finding partial genetic distinction and shared liability to internalising psychopathology.

Statistical fine-mapping of schizophrenia common risk loci using FINEMAP and SuSiE

This paper applies FINEMAP and SuSiE to fine-map schizophrenia risk loci, identifying new genes with high concordance between methods and validating them using LoFI and rare variant enrichment.

Rare coding variants in schizophrenia-associated genes affect generalised cognition in the UK Biobank

The paper investigates the effect of rare coding variants in schizophrenia-associated genes on generalised cognition in the UK Biobank using exome-sequencing data.

Co-expression-based models improve eQTL predictions and highlightnovel transcriptome-wide genes associated with schizophrenia

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

Estimating Disorder Probability Based on Polygenic Prediction Using the BPC Approach

The paper introduces the BPC approach to improve polygenic score calibration for binary disorders, achieving better calibration than existing methods in simulated and empirical data.

Genome-wide analyses of quantitative generalised anxiety symptom severity

This study conducts a genome-wide association analysis of generalised anxiety symptom severity, identifying 80 significant variants and showing genetic correlations with other mental and physical health traits.

Genome-wide meta-analysis of panic attacks and disorder identifies genetic risk factors and implicates multiple body systems in panic and other psychiatric disorders

This study identifies genetic risk factors for panic attacks and disorder through genome-wide meta-analysis and links them to multiple body systems and neuronal functions.

Neurodevelopmental copy number variants increase risk of internalising and cardiometabolic multimorbidity: findings from UK Biobank

The paper investigates the association between neurodevelopmental copy number variants (ND-CNVs) and increased risk of internalising and cardiometabolic multimorbidity using UK Biobank data.

Genetic liability to physical health conditions influences comorbidities in individuals with severe mental illness

The paper examines how genetic risk for physical health conditions affects comorbidities in individuals with severe mental illness, finding stronger genetic associations than psychiatric risk factors.

The relationship between shared and differentiating genetic liability for schizophrenia and bipolar disorder and cognition and educational attainment in the UK Biobank

This paper investigates how genetic liabilities shared and differentiating between schizophrenia and bipolar disorder relate to cognition and educational attainment using UK Biobank data.

Analysis of exome sequencing data implicates rare coding variants in STAG1 and ZNF136 in schizophrenia

This study identifies rare coding variants in STAG1 and ZNF136 associated with schizophrenia using exome sequencing data from 28,898 cases and 103,041 controls.

Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia

The paper investigates genetic risk for schizophrenia by analyzing gene expression and regulatory elements in developing ganglionic eminence neurons.

Rare Variants in Pharmacogenes Influence Clozapine Metabolism in Individuals with Schizophrenia

This study identifies rare genetic variants in pharmacogenes that influence clozapine metabolism in schizophrenia patients, with CYP1A2 variants showing the strongest effect.

Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific NRXN1 disruptions

This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia

The paper uses brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia and identifies enriched networks and genes associated with the disease.

Pathogenic mis-splicing of CPEB4 in schizophrenia

This study identifies aberrant CPEB4 splicing and downstream mis-expression of SCZ-risk genes as a novel etiological mechanism in schizophrenia.

Rare schizophrenia risk variant burden is conserved in diverse human populations

The paper investigates the conservation of rare schizophrenia risk variants across diverse populations and finds consistent burden in constrained genes.

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

This study identifies sex-dependent genetic risk loci shared and specific to mood and psychotic disorders using genome-wide interaction analysis.

Altered brain criticality in Schizophrenia: New insights from MEG

This study examines altered criticality properties in schizophrenia patients using MEG data, finding differences in self-similarity and multifractality gradients compared to healthy controls.

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

The paper identifies shared disruptive coding mutations between schizophrenia, autism spectrum disorders, and other developmental disorders, suggesting overlapping molecular aetiology.

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

This study identifies genetic variants shared between schizophrenia and alcohol use disorder, finding both convergent and divergent effects and evidence of brain tissue expression.

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

The paper compares ten polygenic score methods for psychiatric disorders across multiple cohorts, finding that some methods significantly improve prediction statistics over the baseline PC+T method.

Developmental profile of psychiatric risk associated with voltage-gated cation channel activity

The paper examines the developmental expression of genes related to voltage-gated cation channels and their association with psychiatric disorders, finding that gene expression patterns vary with age and disorder type.

Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

This paper uses Mendelian randomisation to examine the causal effect of antihypertensive drugs on psychiatric disorders, finding an increased schizophrenia risk with lower ACE gene expression.

Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

The paper reports exome sequencing findings in bipolar disorder, identifying AKAP11 as a shared risk gene with schizophrenia through ultra-rare protein-truncating variants.

Identifying genetic variants associated with cerebellar volume in 33,265 individuals from the UK-Biobank

This study identifies 33 genome-wide significant SNPs associated with cerebellar volume in 33,265 UK-Biobank participants, highlighting 21 candidate genes and genetic correlations with other brain structures.

Genetic association of FMRP targets with psychiatric disorders

The paper examines the genetic association of FMRP targets with schizophrenia, major depressive disorder, and bipolar disorder, finding enrichment for risk alleles and variants in these disorders.