Kinneret Keren

β-catenin Dynamics in Regenerating Hydra

This study tracks β-catenin localization during Hydra regeneration, showing its spatial dynamics correlate with head or foot formation in different tissue configurations.

Body-Axis Reorientation in Regenerating Hydra under Geometric Confinement

This study shows that geometric confinement overrides inherited body-axis orientation in regenerating Hydra, leading to reorientation aligned with the confining channel.

Mechanical strain focusing at topological defect sites in regenerating Hydra

This study shows mechanical strain focuses at topological defects during Hydra regeneration, promoting head organizer formation through a feedback loop involving Wnt signaling and biophysical modeling.

Confinement modulates axial patterning in regenerating Hydra

This study shows that mechanical confinement in Hydra regeneration can lead to multiaxial body plans due to nematic topological defects in actomyosin fibers, challenging the idea that axial patterning relies solely on biochemical gradients.