Yonit Maroudas-Sacks

SpinePy provides a framework for 3D spatiotemporal quantification of multicellular systems by aligning data to dynamic internal coordinate systems, revealing patterning classes influenced by gastruloid volume.

This study shows mechanical strain focuses at topological defects during Hydra regeneration, promoting head organizer formation through a feedback loop involving Wnt signaling and biophysical modeling.

This study shows that mechanical confinement in Hydra regeneration can lead to multiaxial body plans due to nematic topological defects in actomyosin fibers, challenging the idea that axial patterning relies solely on biochemical gradients.