Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery
Seung Hyuk Lee, Asha Kar, Sini Heinonen, Marcus Alvarez, Sandhya Rajkumar, Kristina M. Garske, Kyla Z. Gelev, Birgitta W. van der Kolk, Ulla Säiläkivi, Tuure Saarinen, Dorota Kamińska, Ville Männistö, Markku Laakso, Jussi Pihlajamäki, Anne Juuti, , Päivi Pajukanta
This study uses longitudinal single-cell adipose transcriptomics to identify genes and variants associated with weight loss after bariatric surgery and shows that BMI polygenic risk scores predict weight loss outcomes.
medRxiv · Jul 11, 2025 · PreprintGenetic & Genomic Medicine