This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

Aging Cell · Jul 21, 2026Peer-reviewedGenetic & Genomic Medicine

Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue

Zeyuan Johnson Chen, Sankha Subhra Das, Asha Kar, Seung Hyuk Lee, Kevin Daniel Abuhanna, Marcus Alvarez, Mihir G. Sukhatme, Zitian Wang, Kyla Z. Gelev, Matthew G. Heffel, Yi Zhang, Oren Avram, Elior Rahmani, Sriram Sankararaman, Markku Laakso, , Päivi Pajukanta

The paper characterizes the epigenomic and 3D genomic landscape of human subcutaneous adipose tissue at the cell-type level and links epigenomic variation to abdominal obesity risk.

Nature Genetics · Aug 20, 2025Peer-reviewedGenomics

Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery

Seung Hyuk Lee, Asha Kar, Sini Heinonen, Marcus Alvarez, Sandhya Rajkumar, Kristina M. Garske, Kyla Z. Gelev, Birgitta W. van der Kolk, Ulla Säiläkivi, Tuure Saarinen, Dorota Kamińska, Ville Männistö, Markku Laakso, Jussi Pihlajamäki, Anne Juuti, , Päivi Pajukanta

This study uses longitudinal single-cell adipose transcriptomics to identify genes and variants associated with weight loss after bariatric surgery and shows that BMI polygenic risk scores predict weight loss outcomes.

medRxiv · Jul 11, 2025 · PreprintGenetic & Genomic Medicine

Twin pair analysis uncovers novel links between DNA methylation, mitochondrial DNA quantity and obesity

Aino Heikkinen, Vivienne F. C. Esser, Seung Hyuk Lee, Sara Lundgren, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per‐Henrik Groop, Sini Heinonen, Sergio Villicaña, Jordana T. Bell, Alice Maguolo, Emma Nilsson, Charlotte Ling, Allan Arthur Vaag, , Miina Ollikainen

The paper identifies a locus, SH3BP4, where DNA methylation correlates with mtDNAq and obesity-related traits in adipose tissue, suggesting potential causal relationships.

Nature Communications · May 12, 2025Peer-reviewedGenetic & Genomic Medicine

Integration of single cell omics with biobank data discovers trans effects of SREBF1 abdominal obesity risk variants on adipocyte expression of more than 100 genes

Mihir G. Sukhatme, Asha Kar, Uma Thanigai Arasu, Seung Hyuk Lee, Marcus Alvarez, Kristina M. Garske, Kyla Z. Gelev, Sandhya Rajkumar, Sankha Subhra Das, Dorota Kamińska, Ville Männistö, Hilkka H. Peltoniemi, Sini Heinonen, Ulla Säiläkivi, Tuure Saarinen, , Päivi Pajukanta

The paper integrates single-cell omics with biobank data to show SREBF1 risk variants affect adipocyte gene expression in trans, impacting abdominal obesity.

medRxiv · Nov 22, 2024 · PreprintGenetic & Genomic Medicine