Synthetic BiologybioRxivPreprint
Automated Parameterization of Predictive Kinetic Metabolic Models from Sparse Datasets for Efficient Optimization of Many-Enzyme Heterologous Pathways
Sean M. Halper, Iman Farasat, Howard M. Salis
The paper develops an algorithm to predict optimal enzyme expression levels for many-enzyme metabolic pathways using sparse datasets, demonstrating accuracy and noise tolerance.