When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion
Lisa Dengler, Francesco Padovani, Bianca Lemke, Rebecca Brugger, Benedikt Westermann, Boris Maček, Kurt M. Schmoller, Jennifer Christina Ewald
This study shows that impaired mitochondrial fusion in yeast leads to mtDNA loss due to unequal distribution and reduced synthesis.
bioRxiv · May 13, 2025 · PreprintCell Biology