Johan Bielecki

This paper resolves the mechanism of covalent bond formation in a LOV photoreceptor using time-resolved crystallography and spectroscopy, revealing a water-mediated proton transfer that accelerates the reaction by fourteen orders of magnitude.

This paper introduces an aerosol delivery method for serial femtosecond crystallography that reduces background scattering and improves data quality, validated with a 1.9 Å resolution structure of Cydia pomonella granulovirus nanocrystals.

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

This study presents room-temperature structures of PBP2a using SFX to reveal dynamic features and conformational changes relevant to antibiotic resistance.

The paper determines the crystal structure of a bacterial photoactivated adenylate cyclase at room temperature using serial femtosecond crystallography and compares it with cryo structures to study structural changes upon light exposure.

The paper determines the structures of Cry11Aa and Cry11Ba toxins using serial femtosecond crystallography, revealing new insights into their in vivo crystallization patterns and toxicity.