Jose Manuel Martin-Garcia

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

Ambient temperature structural studies of Penicillin-binding Protein 2a of Methicillin-Resistant Staphylococcus aureus with XFELs and synchrotrons

This study presents room-temperature structures of PBP2a using SFX to reveal dynamic features and conformational changes relevant to antibiotic resistance.

Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sites.

This study investigates the role of Tyr126 and Tyr128 in human NQO1 catalysis, showing their critical impact on enzyme activity and non-synchronous catalysis.

Heterogeneity in the M. tuberculosis β-lactamase inhibition by Sulbactam

The paper uses MISC to study Sulbactam inhibition of M. tuberculosis BlaC, revealing heterogeneity, cooperativity, and conformational changes in atomic detail.