Circadian desynchronization desensitizes insulin-producing cells to cytokine-mediated transcriptomic remodeling and cell death: a novel beta-cell anti-apoptotic response to inflammation
Phillip Alexander Keller Andersen, Rasmus H. Reeh, Isabel Sanders, Emilie Bender Overlund, Georgia Katsioudi, Cecilia Jiménez‐Sánchez, Emil Z. Skovhøj, Anniek Frederike Lubberding, Charna Dibner, Thomas R Mandrup-Poulsen
This study shows that circadian desynchronization protects insulin-producing cells from cytokine-induced transcriptomic changes and cell death by modulating NF-κB signaling and clock gene regulation.
iScience · Apr 15, 2025Peer-reviewedCell Biology