Thomas R Mandrup-Poulsen

This study shows that circadian desynchronization protects insulin-producing cells from cytokine-induced transcriptomic changes and cell death by modulating NF-κB signaling and clock gene regulation.

This paper uses a computational model to show that pancreatic islets can switch between transient and persistent inflammation modes based on feedback loops and islet size.

The paper shows that high fat diet affects circadian entrainment to summer and winter photoperiods through PER2 phosphorylation and polyunsaturated fatty acids.

This study identifies FKBP2 as a proline isomerase involved in proinsulin folding, showing its role in preventing misfolding and apoptosis in β-cells.

This study shows that impaired proinsulin handling in β-cells increases MHC-I bound peptides and activates inflammasomes, potentially contributing to autoimmune diabetes.

The paper shows that inducible proteasomal subunits are constitutively expressed in pancreatic beta cells and upregulated by IL-1β, enhancing proteasome activity and potentially influencing autoantigen presentation.