Author

Jacob Scadden

UNSW SydneyORCID 0000-0002-3074-7055Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:bacteria (other)· 2 Research Focus:protein design· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:comparative / phylogenetic analysis· 1 Organism:E. coli· 1 Research Focus:phylogenetics / evolution· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Matthew A. B. BakeriD· 3 shared Jamiema Sara PhilipiD· 2 shared Pietro RidoneiD· 2 shared Yoshiyuki SowaiD· 2 shared Caroline Puente-LelièvreiD· 1 shared Divyangi Pandit· 1 shared Luke McNallyiD· 1 shared Nicholas Joseph MatzkeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

Matthew A. B. BakerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 26, 2026

A Specific Ancestral Sequence Reconstruction of Flagellin Can Drive Motility in Salmonella enterica but not Escherichia coli

Jacob Scadden, Jamiema Sara Philip, Pietro Ridone…·Matthew A. B. Baker

This study uses ancestral sequence reconstruction to generate flagellin sequences and tests their ability to restore motility in E. coli and S. Typhimurium, finding limited sequence tolerance and species-specific differences.

DOI 10.64898/2026.10.20.760431

bacteria (other)proteomics

MicrobiologyJournal of BacteriologyPeer-reviewedAug 11, 2025

Rescue of bacterial motility using two and three-species FliC chimeras

Jacob Scadden, Pietro Ridone, Divyangi Pandit…·Matthew A. B. Baker

The paper engineers FliC chimeras from multiple bacterial species to restore motility in E. coli, finding that two chimeras containing the S. Typhimurium D2 domain successfully rescue motility.

4 citations

E. coliproteomics

MicrobiologyThe ISME JournalPeer-reviewedJan 1, 2025

Mapping the loss of flagellar motility across the tree of life

Jamiema Sara Philip, Sehhaj Grewal, Jacob Scadden…·Matthew A. B. Baker

The paper maps the evolution of flagellar motility across bacterial species by analyzing genome data and developing a classifier to predict motility based on protein homology.

8 citationstop 5%

bacteria (other)whole-genome sequencing