A Specific Ancestral Sequence Reconstruction of Flagellin Can Drive Motility in Salmonella enterica but not Escherichia coli
Jacob Scadden, Jamiema Sara Philip, Pietro Ridone, Yoshiyuki Sowa, Matthew A. B. Baker
This study uses ancestral sequence reconstruction to generate flagellin sequences and tests their ability to restore motility in E. coli and S. Typhimurium, finding limited sequence tolerance and species-specific differences.
bioRxiv · Oct 26, 2026 · PreprintMicrobiology