Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol
Noah Dukler, Gregory T. Booth, Yi-Fei Huang, Nathaniel D. Tippens, Colin T. Waters, Charles G. Danko, John T. Lis, Adam C. Siepel
This study uses PRO-seq to analyze the rapid transcriptional response to celastrol in K562 cells, revealing two waves of transcriptional changes and identifying key transcription factors involved.
Genome Research · Nov 1, 2017Peer-reviewedGenomics