Noah Dukler

Deconvolution of Expression for Nascent RNA Sequencing Data (DENR) Highlights Pre-RNA Isoform Diversity in Human Cells

Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data

The paper introduces a method to estimate RNA half-lives using PRO-seq and RNA-seq data, finding correlations between RNA stability and splicing, miRNA binding, DNA methylation, and histone modifications.

Natural Selection has Shaped Coding and Non-coding Transcription in Primate CD4+ T-cells

The paper compares nascent transcription in primates to identify evolutionary patterns in coding and non-coding transcription, finding that transcription factor binding sites and adaptive substitutions drive species-specific differences.

Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol

This study uses PRO-seq to analyze the rapid transcriptional response to celastrol in K562 cells, revealing two waves of transcriptional changes and identifying key transcription factors involved.