Deletion of NLRP3 gene blocks traumatic brain injury induced abnormal immune response in 3xTg AD mice
Jakob C Green, Zheng Liu, Sarah Timis, Christopher Nelson, Alexandra Pedin, Chunqing Guo, Xiang-Yang Wang, Shijun Zhang, Dong Sun
This study shows that deleting the NLRP3 gene reduces TBI-induced immune changes in 3xTg AD mice, but only in males, highlighting sex-related differences.
bioRxiv · Apr 28, 2026 · PreprintImmunology